Wang Juan, Truong Thomas, Ladiges Warren, Goh Jorming
Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
Interdisciplinary Program in Nutritional Sciences, University of Washington, Seattle, WA, USA.
Pathobiol Aging Age Relat Dis. 2019 Jul 26;9(1):1647746. doi: 10.1080/20010001.2019.1647746. eCollection 2019.
Rapamycin is an immunosuppressive and anti-cancer drug recently shown to enhance healthy aging in animal models. Regular physical exercise is associated with healthy aging and reduced risk of age-related diseases, such as cancer. In order to test the combined effect of these approaches, mice with 4T1 breast cancer were fed rapamycin at 14 ppm and allowed access to voluntary running wheels. After 17 days of treatment, mice fed the rapamycin diet that ran showed a significant increase in tumor burden compared with mice that did not run (P = 0.017). Not only does this have implications for young breast cancer patients, but suggests that combining rapamycin and exercise as an anti-aging strategy at a young age might be contraindicated.
雷帕霉素是一种免疫抑制和抗癌药物，最近在动物模型中显示可促进健康衰老。规律的体育锻炼与健康衰老以及降低患癌症等与年龄相关疾病的风险有关。为了测试这些方法的联合效果，给患有4T1乳腺癌的小鼠喂食浓度为14 ppm的雷帕霉素，并让它们使用自愿跑步轮。治疗17天后，与不跑步的小鼠相比，喂食雷帕霉素饮食且跑步的小鼠肿瘤负担显著增加（P = 0.017）。这不仅对年轻乳腺癌患者有影响，还表明在年轻时将雷帕霉素和运动作为抗衰老策略结合起来可能是禁忌的。
