Carrillo-Larco Rodrigo M, Acevedo-Rodriguez J Gonzalo, Altez-Fernandez Carlos, Ortiz-Acha Karol, Ugarte-Gil Cesar
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Wellcome Open Res. 2019 Jul 23;4:110. doi: 10.12688/wellcomeopenres.15367.1. eCollection 2019.
Cutaneous leishmaniasis is a prevalent communicable disease in low- and middle-income countries, where non-communicable diseases like skin cancer are on the rise. However, the study of multi-morbidity or co-morbidity between communicable and non-communicable diseases is limited, and even null for some tropical or neglected diseases. Nevertheless, looking at these conditions together instead of as isolated entities in places where these illnesses exist, could show new prevention and treatment paths. We aimed to summarize and critically appraise the epidemiological evidence on the association between cutaneous leishmaniasis and skin cancer. Following the PRISMA guidelines, we conducted a systematic review using five search engines (Embase, Medline, Global Health, Scopus and Web of Science). We sought observational studies in which the outcome was skin cancer whilst the exposure was cutaneous leishmaniasis; these conditions should have had laboratory or pathology confirmation. No epidemiological investigations have studied the association between cutaneous leishmaniasis and skin cancer. Most of the evidence about the association of interest is still based on case reports and other clinical observations rather than strong epidemiological observational studies. Research is much needed to verify the repeatedly clinical observation that cutaneous leishmaniasis may be a risk factor for skin cancer. This evidence could inform and guide early diagnosis or prevention of skin cancer in survivors of cutaneous leishmaniasis or where cutaneous leishmaniasis is still highly prevalent. PROSPERO ID CRD42018111230; registered on 16/10/18.
皮肤利什曼病是低收入和中等收入国家的一种常见传染病，而在这些国家，皮肤癌等非传染性疾病的发病率正在上升。然而，关于传染病和非传染病之间的多重疾病或共病研究有限，对于某些热带病或被忽视的疾病甚至为零。尽管如此，在这些疾病共存的地区将这些疾病综合起来看待，而非孤立地看待，可能会展现出新的预防和治疗途径。我们旨在总结并批判性地评估关于皮肤利什曼病与皮肤癌之间关联的流行病学证据。遵循PRISMA指南，我们使用五个搜索引擎（Embase、Medline、Global Health、Scopus和Web of Science）进行了系统综述。我们寻找以皮肤癌为结局、皮肤利什曼病为暴露因素的观察性研究；这些疾病应经过实验室或病理学确诊。尚无流行病学调查研究过皮肤利什曼病与皮肤癌之间的关联。关于感兴趣的关联的大多数证据仍基于病例报告和其他临床观察，而非强有力的流行病学观察性研究。迫切需要开展研究以验证皮肤利什曼病可能是皮肤癌的危险因素这一反复出现的临床观察结果。这一证据可为皮肤利什曼病幸存者或皮肤利什曼病仍高度流行地区的皮肤癌早期诊断或预防提供信息并加以指导。PROSPERO编号CRD42018111230；于2018年10月16日注册。
