Department of Internal Medicine and Cardiology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum Augustenburgerplatz 1, 13353, Berlin, Germany.
German Center for Cardiovascular Research (DZHK), Berlin, Germany.
Heart Fail Rev. 2020 Jan;25(1):67-73. doi: 10.1007/s10741-019-09853-7.
In recent years, several studies have shown the usefulness and clinical relevance of left ventricular global longitudinal systolic strain (GLS) in different cardiovascular diseases. In line with this, the role of GLS in patients with heart failure with preserved ejection fraction (HFpEF) has achieved great importance in this predominant form of heart failure in the last years. In this regard, GLS has shown to be not only a sensitive parameter to detect subtle myocardial abnormalities but also a parameter of clinical and prognostic relevance in patients with HFpEF. In this review, we analyze the current evidence concerning the clinical relevance of GLS in patients with HFpEF and we discuss the potential usefulness of GLS in this complex and heterogeneous condition for which so far no effective therapy exists.
近年来，多项研究表明左心室整体纵向收缩应变（GLS）在不同心血管疾病中的有用性和临床相关性。与此一致的是，GLS 在射血分数保留型心力衰竭（HFpEF）患者中的作用近年来在这种主要心力衰竭形式中变得非常重要。在这方面，GLS 不仅是检测细微心肌异常的敏感参数，而且是 HFpEF 患者临床和预后相关的参数。在这篇综述中，我们分析了 GLS 在 HFpEF 患者中的临床相关性的现有证据，并讨论了 GLS 在这种复杂和异质情况下的潜在用途，迄今为止尚无有效的治疗方法。
