Université Côte d'Azur, CNRS, IPMC, 660 route des Lucioles, 06560, Valbonne, France.
Neuromolecular Med. 2019 Dec;21(4):432-444. doi: 10.1007/s12017-019-08563-5. Epub 2019 Sep 5.
Diabetes affects more than 425 million people worldwide, a scale approaching pandemic proportion. Diabetes represents a major risk factor for stroke, and therefore is actively addressed for stroke prevention. However, how diabetes affects stroke severity has not yet been extensively considered, which is surprising given the evident but understudied common mechanistic features of both pathologies. The increase in number of diabetic people, incidence of stroke in the presence of this specific risk factor, and the exacerbation of ischemic brain damage in diabetic conditions (at least in animal models) warrants the need to integrate this comorbidity in preclinical studies of brain ischemia to develop novel therapeutic approaches. Therefore, a better understanding of the commonalties involved in the course of both diseases would offer the promise of discovering novel neuroprotective pathways that would be more appropriated to clinical scenarios. In this article, we will review the relevant mechanisms that have been identified as common traits of both pathologies and that could be, to our knowledge, potential targets in both pathologies.
糖尿病影响着全球超过 4.25 亿人，其规模接近大流行的比例。糖尿病是中风的一个主要危险因素，因此积极针对其进行中风预防。然而，糖尿病如何影响中风的严重程度尚未得到广泛考虑，这令人惊讶，因为这两种疾病的明显但研究不足的共同机制特征是显而易见的。糖尿病患者数量的增加、存在这种特定风险因素时中风的发生率，以及糖尿病情况下缺血性脑损伤的恶化（至少在动物模型中）都证明了需要将这种合并症纳入脑缺血的临床前研究中，以开发新的治疗方法。因此，更好地了解这两种疾病过程中的共同性将有望发现新的神经保护途径，这些途径更适合临床情况。在本文中，我们将回顾已确定为这两种疾病共同特征的相关机制，这些机制可能是我们所知的这两种疾病的潜在靶点。
