Casey P B, Buckley B M, Vale J A
National Poisons Information Service (Birmingham Center), West Midlands Poisons Unit, Dudley Road Hospital, Birmingham, United Kingdom.
J Toxicol Clin Toxicol. 1994;32(2):185-9. doi: 10.3109/15563659409000449.
A 59-year-old man ingested a mouthful of Gramonol with suicidal intent and was admitted to a local hospital six and a half hours later. It was noted that he looked "ashen grey" and was centrally cyanosed. The methemoglobin and plasma paraquat concentrations performed on arrival at the Regional Poisons Treatment Unit eight hours after paraquat ingestion were 52% and 1100 micrograms/L respectively; the administration of methylene blue reversed methemoglobinemia within two hours. The patient suffered extensive paraquat-induced oral, and probably esophageal, ulceration and developed multiple organ (particularly renal, respiratory and hepatic) failure and died some 10 days later. This is the most severe case of Gramonol poisoning reported both in terms of the amount of paraquat ingested and the concentration of methemoglobin formed. We believe that the methemoglobinemia in this patient was caused by monolinuron not paraquat.
一名59岁男子出于自杀意图吞服了一口Gramonol，6个半小时后被送往当地医院。据观察，他面色“灰黑”，出现中央性发绀。在摄入百草枯8小时后抵达地区中毒治疗单元时测得的高铁血红蛋白和血浆百草枯浓度分别为52%和1100微克/升；亚甲蓝给药两小时内逆转了高铁血红蛋白血症。患者出现了广泛的百草枯所致口腔（可能还有食管）溃疡，并发展为多器官（尤其是肾脏、呼吸和肝脏）衰竭，约10天后死亡。就摄入的百草枯量和形成的高铁血红蛋白浓度而言，这是所报道的最严重的Gramonol中毒病例。我们认为该患者的高铁血红蛋白血症是由绿谷隆而非百草枯引起的。
