Ntzouvani Agathi, Giannopoulou Efstathia, Fragopoulou Elizabeth, Nomikos Tzortzis, Antonopoulou Smaragdi
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Eleftheriou Venizelou 70, Athens, 17671, Greece.
Lipids. 2019 Oct;54(10):629-640. doi: 10.1002/lipd.12191. Epub 2019 Sep 6.
Lipoprotein-associated phospholipase A (Lp-PLA ) is associated with increased risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus. Lp-PLA activity is positively associated with male sex, Caucasian race, the presence of metabolic syndrome (MetS) and low-density lipoprotein (LDL)-cholesterol, but it is negatively associated with high-density lipoprotein (HDL)-cholesterol. Associations with other cardiometabolic risk factors, inflammation markers, and lifestyle factors are few or inconsistent. We investigated potential determinants of Lp-PLA activity among both nonmodifiable and modifiable CVD risk factors in a middle-aged Greek cohort without overt CVD. Two hundred eighty four subjects (159 men, 53 ± 9 years and 125 women 52 ± 9 years) participated in a cross-sectional study carried out during 2011-2012 in Athens, Attica. Cardiometabolic risk factors, inflammation markers, lifestyle factors, and Lp-PLA activity were evaluated with established methods. The American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) criteria were used to define MetS. Lp-PLA activity was not associated with MetS, but was associated with MetS components, markers of liver function, and macronutrient intake. Increased total energy intake was associated with increased Lp-PLA activity (odds ratio, 95% confidence interval: 1.07, 1.01-1.14 and 1.10, 1.03-1.16 for the 4th and 3rd quartiles, respectively, compared to the 1st quartile) after adjustments for sex, pack-years of smoking, LDL-cholesterol, and statin treatment. Adiponectin tended to be inversely associated with Lp-PLA activity (0.91, 0.82-1.00, and 4th versus 1st quartile). Our results suggested that total energy intake and adiponectin levels are potential determinants of Lp-PLA activity.
脂蛋白相关磷脂酶A2（Lp-PLA2）与心血管疾病（CVD）和2型糖尿病风险增加相关。Lp-PLA2活性与男性、白种人、代谢综合征（MetS）的存在以及低密度脂蛋白（LDL）胆固醇呈正相关，但与高密度脂蛋白（HDL）胆固醇呈负相关。与其他心血管代谢危险因素、炎症标志物和生活方式因素的关联较少或不一致。我们在一个无明显CVD的中年希腊队列中，研究了不可改变和可改变的CVD危险因素中Lp-PLA2活性的潜在决定因素。284名受试者（159名男性，年龄53±9岁；125名女性，年龄52±9岁）参与了2011年至2012年在阿提卡雅典进行的一项横断面研究。采用既定方法评估心血管代谢危险因素、炎症标志物、生活方式因素和Lp-PLA2活性。采用美国心脏协会/美国国立心肺血液研究所（AHA/NHLBI）标准定义MetS。Lp-PLA2活性与MetS无关，但与MetS组分、肝功能标志物和常量营养素摄入有关。在调整了性别、吸烟包年数、LDL胆固醇和他汀类药物治疗后，总能量摄入增加与Lp-PLA2活性增加相关（第四和第三四分位数与第一四分位数相比，优势比，95%置信区间：分别为1.07，1.01 - 1.14和1.10，1.03 - 1.16）。脂联素倾向于与Lp-PLA2活性呈负相关（0.91，0.82 - 1.00，第四四分位数与第一四分位数相比）。我们的结果表明，总能量摄入和脂联素水平是Lp-PLA2活性的潜在决定因素。
