Brilakis Emmanouil S, Khera Amit, McGuire Darren K, See Raphael, Banerjee Subhash, Murphy Sabina A, de Lemos James A
The Donald W. Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center in Dallas, TX, United States.
Atherosclerosis. 2008 Jul;199(1):110-5. doi: 10.1016/j.atherosclerosis.2007.10.010. Epub 2007 Dec 3.
Most lipoprotein-associated phospholipase A2 (Lp-PLA2) studies included mainly white men. We sought to determine whether Lp-PLA2 levels differ according to race and sex.
Lp-PLA2 mass and activity were measured in 3332 subjects age 30-65 participating in the Dallas Heart Study, a multiethnic, population-based, probability sample. Lp-PLA2 levels were compared between different race and sex groups.
Mean age was 45+/-9 years and 44% were men; 30% were white, 17% hispanic, and 53% black. Mean Lp-PLA2 activity and mass were 146+/-40 nmol/min/mL and 191+/-60 ng/mL, respectively. Lp-PLA2 activity was lower in women compared with men (134+/-35 vs. 161+/-40, p=0.001) and was lowest in black (136+/-38), intermediate in hispanic (151+/-36), and highest in white subjects (161+/-39) (trend p=0.0001). In multivariable linear regression models, after adjusting for age, body mass index (BMI), smoking, total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglycerides and high sensitivity C-reactive protein (hsCRP), Lp-PLA2 activity was 19 nmol/min/mL higher in men vs. women (p<0.001); compared with black subjects, adjusted Lp-PLA2 activity was 11 and 20 nmol/min/mL higher in white and hispanic subjects, respectively (both p<0.001). Similar race and sex differences were observed for Lp-PLA2 mass.
Race and sex independently influence Lp-PLA2 activity and mass. Thresholds to define Lp-PLA2 elevation may need to be sex and race specific.
大多数脂蛋白相关磷脂酶A2（Lp-PLA2）研究主要纳入白人男性。我们试图确定Lp-PLA2水平是否因种族和性别而异。
在参与达拉斯心脏研究的3332名30至65岁受试者中测量Lp-PLA2质量和活性，该研究是一个基于人群的多民族概率样本。比较不同种族和性别组之间的Lp-PLA2水平。
平均年龄为45±9岁，44%为男性；30%为白人，17%为西班牙裔，53%为黑人。Lp-PLA2活性和质量的平均值分别为146±40 nmol/分钟/毫升和191±60 ng/毫升。女性的Lp-PLA2活性低于男性（134±35对161±40，p = 0.001），在黑人中最低（136±38），在西班牙裔中居中（151±36），在白人受试者中最高（161±39）（趋势p = 0.0001）。在多变量线性回归模型中，在调整年龄、体重指数（BMI）、吸烟、总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇、甘油三酯和高敏C反应蛋白（hsCRP）后，男性的Lp-PLA2活性比女性高19 nmol/分钟/毫升（p < 0.001）；与黑人受试者相比，白人和西班牙裔受试者调整后的Lp-PLA2活性分别高11和20 nmol/分钟/毫升（均p < 0.001）。Lp-PLA2质量也观察到类似的种族和性别差异。
种族和性别独立影响Lp-PLA2活性和质量。定义Lp-PLA2升高的阈值可能需要根据性别和种族而定。
