Department of Retina and Vitreous, Narayana Nethralaya, Bangalore, India.
Clin Exp Optom. 2020 May;103(3):324-331. doi: 10.1111/cxo.12965. Epub 2019 Sep 6.
Multicolour imaging (MI) is a novel, non-invasive retinal imaging technology. Its sensitivity for detecting the clinical features in central serous chorioretinopathy (CSCR) has not been previously described. The aim of this study is to evaluate the accuracy of MI compared to fluorescein angiography and colour fundus photography in CSCR, and to describe the imaging features of MI.
In this retrospective study at a tertiary referral centre, 63 consecutive eyes with CSCR (both acute and chronic) were included after obtaining permission from the institutional review board. Multimodal imaging with colour fundus photography, optical coherence tomography, MI and fluorescein angiography/indocyanine green angiography and near-infrared and blue wavelength autofluorescence was analysed to identify the clinical findings in CSCR. Sensitivity and specificity values were computed for the different clinical features for each imaging modality.
On comparison with fluorescein angiography, MI was found to be more effective in identifying the extent of subretinal fluid (78 per cent versus 13 per cent). MI was equally capable in identifying pigment epithelium detachment (100 per cent versus 100 per cent) and retinal pigment epithelial changes (100 per cent versus 100 per cent). Focal leaks were identified in 84 per cent and 97 per cent of eyes using MI and fluorescein angiography imaging, respectively. The sensitivity of MI in identifying focal retinal pigment epithelial leaks was higher compared to near-infrared autofluorescence (84 per cent versus 34 per cent) and blue wavelength autofluorescence (84 per cent versus 18 per cent) imaging.
MI is a useful, non-invasive imaging modality for detecting clinical features in CSCR. In the future, MI has the potential to substitute for fluorescein angiography and colour fundus photography as the imaging modality of choice.
多色成像（MI）是一种新颖的、非侵入性的视网膜成像技术。其在检测中心性浆液性脉络膜视网膜病变（CSCR）的临床特征方面的敏感性尚未被描述。本研究旨在评估 MI 相对于荧光素血管造影和彩色眼底摄影在 CSCR 中的准确性，并描述 MI 的成像特征。
在这项回顾性研究中，在获得机构审查委员会的许可后，我们纳入了 63 只连续的 CSCR 眼（包括急性和慢性）。对彩色眼底摄影、光学相干断层扫描、MI 以及荧光素血管造影/吲哚青绿血管造影和近红外和蓝色波长自发荧光进行多模态成像，以识别 CSCR 中的临床发现。计算了每种成像方式的不同临床特征的敏感性和特异性值。
与荧光素血管造影相比，MI 在识别视网膜下液的范围方面更为有效（78%比 13%）。MI 在识别色素上皮脱离（100%比 100%）和视网膜色素上皮变化（100%比 100%）方面同样有效。使用 MI 和荧光素血管造影成像分别在 84%和 97%的眼中识别出局灶性渗漏。MI 在识别局灶性视网膜色素上皮渗漏方面的敏感性高于近红外自发荧光（84%比 34%）和蓝色波长自发荧光（84%比 18%）成像。
MI 是一种用于检测 CSCR 临床特征的有用的、非侵入性成像方式。在未来，MI 有可能替代荧光素血管造影和彩色眼底摄影成为首选的成像方式。
