Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neuromodulation. 2020 Jul;23(5):660-666. doi: 10.1111/ner.13044. Epub 2019 Sep 6.
Determining reduction in pain score during spinal cord stimulation (SCS) trial is important prior to permanent SCS implantation. However, this association remains elusive. We investigate the association between post-SCS pain scores and successful permanent SCS implants.
This IRB-approved, retrospective study identified patients who underwent SCS trials and implantation. Predictive modeling with nonparametric regression and margins plot analysis was used to determine the threshold for post-SCS trial pain scores associated with successful permanent SCS implant (defined as >50% pain relief). Nonparametric sensitivity and specificity analysis was performed. p < 0.05 was considered significant.
Eighty-eight patients with SCS trials were retrospectively identified (57.95% female, median age 52.5 ± 15.5 years). Of the total cohort, 79% had successful permanent SCS implantation. Post-SCS trial pain scores less than or equal to 4.9 had greater than 50% probability of a successful permanent SCS implant (97.14% sensitivity, 44.44% specificity, ROC = 0.71). Post-SCS trial pain scores between 4 and 7 were associated with a significantly higher probability of a successful SCS implant among patients without spine surgery compared with those with a history of spine surgery. Compared with males, females with pain scores between 5 and 7 had a higher probability of a successful SCS implant.
Low pain scores after SCS trial are predictive of successful SCS implants with high sensitivity. Males and surgical patients with higher pain scores had a lower probability of successful SCS implant than their counterparts. Larger studies are needed to further elucidate this relationship.
在进行脊髓刺激 (SCS) 试验之前,确定疼痛评分的降低对于永久性 SCS 植入至关重要。然而,这种关联仍然难以捉摸。我们研究了 SCS 试验后疼痛评分与成功的永久性 SCS 植入之间的关联。
这项经过机构审查委员会批准的回顾性研究确定了接受 SCS 试验和植入的患者。使用非参数回归和边缘图分析进行预测建模,以确定与成功的永久性 SCS 植入相关的 SCS 试验后疼痛评分阈值(定义为 >50% 的疼痛缓解)。进行了非参数敏感性和特异性分析。p < 0.05 被认为具有统计学意义。
回顾性确定了 88 例接受 SCS 试验的患者(57.95%为女性,中位年龄为 52.5 ± 15.5 岁)。在总队列中,79%的患者进行了成功的永久性 SCS 植入。SCS 试验后疼痛评分等于或小于 4.9 分的患者具有超过 50%的成功永久性 SCS 植入概率(97.14%的敏感性,44.44%的特异性,ROC = 0.71)。与没有脊柱手术史的患者相比,SCS 试验后疼痛评分在 4 到 7 之间的患者更有可能成功植入 SCS。与男性相比,疼痛评分在 5 到 7 之间的女性更有可能成功植入 SCS。
SCS 试验后疼痛评分低是成功 SCS 植入的预测因素,具有高敏感性。疼痛评分较高的男性和接受过脊柱手术的患者成功植入 SCS 的可能性低于其对应者。需要更大规模的研究来进一步阐明这种关系。