Begum Feroza, Das Sandeepan, Mukherjee Debica, Ray Upasana
CSIR-Indian Institute of Chemical Biology; 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Microorganisms. 2019 Sep 6;7(9):323. doi: 10.3390/microorganisms7090323.
Dengue virus (DENV) is one of the lethal pathogens in the hot climatic regions of the world and has been extensively studied to decipher its mechanism of pathogenesis and the missing links of its life cycle. With respect to the entry of DENV, multiple receptors have been recognized in different cells of the human body. However, scientists still argue whether these identified receptors are the exclusive entry mediators for the virus. Adding to the complexity, DENV has been reported to be infecting multiple organ types in its human host. Also, more than one receptor in a particular cell has been discerned to take part in mediating the ingress of DENV. In this review, we aim to discuss the different cells of the human immune system that support DENV infection and their corresponding receptors that DENV deploy to gain access to the cells.
登革病毒（DENV）是世界炎热气候地区的致命病原体之一，人们对其进行了广泛研究，以破解其发病机制及其生命周期中缺失的环节。关于登革病毒的进入，人体不同细胞中已识别出多种受体。然而，科学家们仍在争论这些已识别的受体是否是病毒唯一的进入介质。更复杂的是，据报道登革病毒会感染其人类宿主中的多种器官类型。此外，已发现特定细胞中的不止一种受体参与介导登革病毒的进入。在本综述中，我们旨在讨论支持登革病毒感染的人类免疫系统的不同细胞及其相应的受体，登革病毒利用这些受体进入细胞。
