Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia.
Front Immunol. 2018 Sep 26;9:2180. doi: 10.3389/fimmu.2018.02180. eCollection 2018.
Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than seventy small, positive-sense, single-stranded RNA viruses, which are responsible for a spectrum of human and animal diseases ranging in symptoms from mild, influenza-like infection to fatal encephalitis and haemorrhagic fever. Despite genomic and structural similarities across the genus, infections by different flaviviruses result in disparate clinical presentations. This review focusses on two haemorrhagic flaviviruses, dengue virus and yellow fever virus, and two neurotropic flaviviruses, Japanese encephalitis virus and Zika virus. We review current knowledge on host-pathogen interactions, virus entry strategies and tropism.
黄病毒是新兴和再现的节肢动物传播病原体，在全球范围内造成了重大的死亡率和发病率。该属包括七十多种小型、正链、单链 RNA 病毒，可引起一系列人类和动物疾病，症状从轻微的流感样感染到致命的脑炎和出血热不等。尽管整个属在基因组和结构上具有相似性，但不同黄病毒的感染导致不同的临床表现。这篇综述集中讨论了两种出血性黄病毒，登革热病毒和黄热病病毒，以及两种神经毒性黄病毒，日本脑炎病毒和寨卡病毒。我们回顾了宿主-病原体相互作用、病毒进入策略和嗜性的最新知识。
