Yap Sally S L, Nguyen-Khuong Terry, Rudd Pauline M, Alonso Sylvie
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology program, Life Sciences Institute, National University of SingaporeSingapore, Singapore.
Analytics Group, Bioprocessing Technology Institute, A∗STARSingapore, Singapore.
Front Microbiol. 2017 Jul 25;8:1415. doi: 10.3389/fmicb.2017.01415. eCollection 2017.
In many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. glycoproteins, envelope protein (E) and non-structural protein 1 (NS1) are two popular sub-unit vaccine candidates. E protein on the virion surface is the major target of neutralizing antibodies. NS1 which is secreted during DENV infection has been shown to induce a variety of host responses through its binding to several host factors. However, despite their critical role in disease and protection, the glycosylated variants of these two proteins and their biological importance have remained understudied. In this review, we seek to provide a comprehensive summary of the current knowledge on protein glycosylation in DENV, and its role in virus biogenesis, host cell receptor interaction and disease pathogenesis.
在许多由病毒或细菌引起的传染病中，病原体糖蛋白在感染周期中发挥着重要作用，从进入宿主细胞到成功进行细胞内复制以及逃避宿主免疫。登革热也不例外。糖蛋白、包膜蛋白（E）和非结构蛋白1（NS1）是两种常见的亚单位疫苗候选物。病毒粒子表面的E蛋白是中和抗体的主要靶标。登革病毒感染期间分泌的NS1已被证明通过与多种宿主因子结合诱导多种宿主反应。然而，尽管它们在疾病和保护中起着关键作用，但这两种蛋白的糖基化变体及其生物学重要性仍未得到充分研究。在本综述中，我们试图全面总结目前关于登革病毒中蛋白质糖基化的知识，及其在病毒生物发生、宿主细胞受体相互作用和疾病发病机制中的作用。
