School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Nantou, Taiwan; Department of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan.
Department of Education and Research, Taipei City Hospital, Taipei, Taiwan; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan.
Clin Nutr. 2019 Jun;38(3):1368-1372. doi: 10.1016/j.clnu.2018.06.930. Epub 2018 Jun 13.
BACKGROUND & AIMS: Alcohol consumption correlates with type 2 diabetes through its effects on insulin resistance, changes in alcohol metabolite levels, and anti-inflammatory effects. We aim to clarify association between frequency of alcohol consumption and risk of diabetes in Taiwanese population.
The National Health Interview Survey (NHIS) in 2001, 2005, and 2009 selected a representative sample of Taiwan population using a multistage sampling design. Information was collected by standardized face to face interview. Study subjects were connected to the Taiwan National Health Insurance claims dataset and National Register of Deaths Dataset from 2000 to 2013. Kaplan-Meier curve with log rank test was employed to assess the influence of alcohol drinking on incidence of diabetes. Univariate and multivariate Cox proportional regression were used to recognize risk factors of diabetes.
A total of 43,000 participants were included (49.65% male; mean age, 41.79 ± 16.31 years). During the 9-year follow-up period, 3650 incident diabetes cases were recognized. Kaplan-Meier curves comparing the four groups of alcohol consumption frequency showed significant differences (p < 0.01). After adjustment for potentially confounding variables, compared to social drinkers, the risks of diabetes were significantly higher for non-drinkers (adjusted hazard ratio [AHR] = 1.21; 95% confidence interval [CI], 1.09-1.34; p < 0.01), regular drinkers (AHR = 1.19; 95% CI, 1.06-1.35; p < 0.01), and heavy drinkers (AHR = 2.21, 95% CI, 1.56-3.13, p < 0.01).
Social drinkers have a significantly decreased risk of new-onset diabetes compared with non-, regular, and heavy drinkers.
饮酒通过影响胰岛素抵抗、改变酒精代谢物水平和发挥抗炎作用与 2 型糖尿病相关。我们旨在阐明台湾人群中饮酒频率与糖尿病风险之间的关联。
2001 年、2005 年和 2009 年的全国健康访谈调查（NHIS）采用多阶段抽样设计，选择台湾人群的代表性样本。信息通过标准化的面对面访谈收集。研究对象与 2000 年至 2013 年的台湾全民健康保险理赔数据集和全国死亡登记数据集相关联。采用对数秩检验的 Kaplan-Meier 曲线评估饮酒对糖尿病发病的影响。采用单变量和多变量 Cox 比例风险回归识别糖尿病的危险因素。
共纳入 43000 名参与者（49.65%为男性；平均年龄为 41.79±16.31 岁）。在 9 年的随访期间，共发现 3650 例新发糖尿病病例。比较 4 组饮酒频率的 Kaplan-Meier 曲线显示差异具有统计学意义（p<0.01）。在调整潜在混杂因素后，与社交饮酒者相比，非饮酒者（调整后的危险比 [AHR]为 1.21；95%置信区间 [CI]为 1.09-1.34；p<0.01）、规律饮酒者（AHR 为 1.19；95%CI 为 1.06-1.35；p<0.01）和重度饮酒者（AHR 为 2.21；95%CI 为 1.56-3.13；p<0.01）发生糖尿病的风险显著更高。
与非饮酒者、规律饮酒者和重度饮酒者相比，社交饮酒者发生新发糖尿病的风险显著降低。
