Aljomah Ahmed S, Hammami Muhammad M
From the Clinical Studies and Empirical Ethics Department, King Faisal Specialist Hospital and Research Centre.
Ann Plast Surg. 2020 Feb;84(2):e7-e9. doi: 10.1097/SAP.0000000000001966.
Circumferential negative pressure wound therapy is commonly used to manage wounds and enhance the healing process. A theoretical concern was recently raised that circumferential negative pressure wound therapy may have a negative effect on perfusion distally.
In a randomized study, we applied circumferential negative pressure (125 mm Hg) to the midarm of 13 healthy volunteers through InfoV.A.C. Therapy Unit device. The pressure was applied intermittently (5 minutes on and 2 minutes off) for 9 hours. The same device without negative pressure was applied to the contralateral midarm as control. Bilateral index finger O2 saturation (SpO2) was measured every 30 minutes using digital pulse oximetry.
Mean (SD) age of the volunteers was 32.2 (9.5) years, and 61.5% were male. Mean (SD) area under the curve from time 0 to 9 hours of SpO2 was 890.56 (6.69) and 889.71 (6.23) %xh in the intervention and control arms, respectively (P = 0.35). O2 saturation was ≥94% at all observation times in both arms, and no adverse events were identified.
Circumferential negative intermittent pressure of 125 mm Hg applied to the midarm of healthy volunteers for 9 hours does not adversely affect digital SpO2.
环形负压伤口治疗常用于处理伤口并促进愈合过程。最近有人提出理论担忧，即环形负压伤口治疗可能对远端灌注产生负面影响。
在一项随机研究中，我们通过InfoV.A.C.治疗单元设备对13名健康志愿者的上臂中部施加环形负压（125毫米汞柱）。压力间歇施加（5分钟开启和2分钟关闭），持续9小时。将无负压的同一设备应用于对侧上臂中部作为对照。使用数字脉搏血氧饱和度仪每30分钟测量双侧食指血氧饱和度（SpO2）。
志愿者的平均（标准差）年龄为32.2（9.5）岁，61.5%为男性。干预组和对照组从0至9小时SpO2曲线下的平均（标准差）面积分别为890.56（6.69）和889.71（6.23）%xh（P = 0.35）。双臂在所有观察时间的血氧饱和度均≥94%，且未发现不良事件。
对健康志愿者上臂中部施加125毫米汞柱的环形负间歇压9小时不会对数字SpO2产生不利影响。
