玻璃体切除术后润滑剂对角膜厚度的影响。
EFFECT OF LUBRICANTS ON CORNEAL THICKNESS AFTER VITRECTOMY.
机构信息
Emory University School of Medicine, Atlanta, Georgia.
University of Colorado, Denver, Colorado; and.
出版信息
Retina. 2020 Aug;40(8):1616-1622. doi: 10.1097/IAE.0000000000002639.
PURPOSE
This study examines the impact of corneal surface lubricants used during pars plana vitrectomy on corneal edema.
METHODS
This prospective, observational, clinical study occurred at an academic institution. Participants were individuals aged 18 years and older who had already consented to undergo pars plana vitrectomy, without pre-existing corneal pathology. A corneal lubricant was chosen by the surgeon. Corneal thickness was measured preoperatively and postoperatively using pachymetry and anterior segment optical coherence tomography (AS-OCT). Main outcome measure was change in corneal thickness as measured by pachymetry.
RESULTS
Forty-one patients completed the study protocol. The 23 subjects in the SHCS group had a significantly smaller increase in corneal thickness as measured by pachymetry compared with the 18 subjects in the HPMC group (29.9 μm vs. 58.1 μm, P value 0.02). When measured by anterior segment optical coherence tomography, the SHCS group had a smaller increase in corneal thickness compared with the HPMC group (0.04 mm vs. 0.06 mm, P value 0.09) but did not reach significance.
CONCLUSION
SHCS is associated with reduced postoperative increase in corneal pachymetry as compared to HPMC.
目的
本研究旨在探讨在玻璃体切除术期间使用的角膜表面润滑剂对角膜水肿的影响。
方法
这是一项在学术机构进行的前瞻性、观察性临床研究。参与者为年龄在 18 岁及以上、已同意接受玻璃体切除术且无预先存在的角膜病变的个体。由外科医生选择角膜润滑剂。使用角膜测厚仪和眼前段光学相干断层扫描（AS-OCT）在术前和术后测量角膜厚度。主要观察指标为角膜测厚术测量的角膜厚度变化。
结果
41 名患者完成了研究方案。与 HPMC 组的 18 名患者相比，SHCS 组的 23 名患者的角膜厚度增加明显较小（29.9μm 比 58.1μm，P 值 0.02）。使用眼前段光学相干断层扫描测量时，SHCS 组的角膜厚度增加较 HPMC 组小（0.04mm 比 0.06mm，P 值 0.09），但未达到显著水平。
结论
与 HPMC 相比，SHCS 可减少术后角膜厚度的增加。
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