Gevers Leuven J A, Kluft C, Bertina R M, Hessel L W
J Lab Clin Med. 1987 Jun;109(6):631-6.
We studied the effects on plasma levels of coagulation and fibrinolysis factors of two currently used "sub-50" oral contraceptive preparations (OCs), one containing 750 micrograms lynestrenol and 37.5 micrograms ethinyl estradiol (LYN-EE) and the other containing 150 micrograms levonorgestrel and 30 micrograms ethinyl estradiol (LNG-EE), in groups of about 25 women aged 21 +/- 2 years. After 3 months, plasminogen levels increased in the two experimental groups (LYN-EE and LNG-EE), by 40% and 32%, respectively. This change was positively correlated with changes in ceruloplasmin levels, indicating that an estrogenic effect might be involved. Histidine-rich glycoprotein concentration decreased by 26% and 16%, respectively. Tissue-type plasminogen activator (t-PA) activity increased by 260% and 167%; t-PA antigen decreased by 12% and 18%, and t-PA inhibitor activity decreased by 31% and 32%, respectively. In the coagulation system, in both groups factor XII increased by 47% and 34%, respectively. The main inhibitor of factor XII, C1-inactivator, decreased slightly, but this was significant only in the LNG-EE group. The von Willebrand factor antigen fell by 8% and 9%, whereas factor VIII activity did not change. Antithrombin III antigen decreased by 14% in both groups. Factor IX activity increased by 15% and 21%. The difference in hormonal effects of both preparations was reflected by the increases in sex hormone binding globulin (by 130% and 21%) and ceruloplasmin (by 98% and 51%), indicating that LYN-EE had a more estrogenic potency than LNG-EE. In a control group of 25 matched subjects, who were observed simultaneously, we found no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)
我们研究了两种目前使用的“50微克以下”口服避孕药制剂（OCs）对血浆凝血和纤溶因子水平的影响，一种含有750微克炔诺酮和37.5微克炔雌醇（LYN - EE），另一种含有150微克左炔诺孕酮和30微克炔雌醇（LNG - EE），研究对象为约25名年龄在21±2岁的女性。3个月后，两个实验组（LYN - EE组和LNG - EE组）的纤溶酶原水平分别升高了40%和32%。这种变化与血浆铜蓝蛋白水平的变化呈正相关，表明可能涉及雌激素效应。富含组氨酸糖蛋白浓度分别下降了26%和16%。组织型纤溶酶原激活剂（t - PA）活性分别升高了260%和167%；t - PA抗原分别下降了12%和18%，t - PA抑制剂活性分别下降了31%和32%。在凝血系统中，两组的因子Ⅻ分别升高了47%和34%。因子Ⅻ的主要抑制剂C1 - 灭活剂略有下降，但仅在LNG - EE组有显著意义。血管性血友病因子抗原下降了8%和9%，而因子Ⅷ活性未改变。两组的抗凝血酶Ⅲ抗原均下降了14%。因子Ⅸ活性分别升高了15%和21%。两种制剂激素效应的差异体现在性激素结合球蛋白（分别升高130%和21%）和血浆铜蓝蛋白（分别升高98%和51%）的升高上，表明LYN - EE的雌激素效力比LNG - EE更强。在同时观察的25名匹配对照受试者组成的对照组中，我们未发现显著变化。（摘要截选至250词）
