通过异丙醇介导的醋酸烯丙酯还原偶联反应实现手性铱催化炔基酮的对映选择性烯丙基化：普乐地尔 D 的 C14-C23 片段。
Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D.
机构信息
University of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX, 78712-1167, USA.
出版信息
Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18803-18807. doi: 10.1002/anie.201908939. Epub 2019 Nov 7.
Abstract
Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.
摘要
在脂肪族或芳香族酮的存在下，高对映选择性催化还原偶联烯丙基乙酸酯与炔酮以化学选择性方式发生。该方法用于构建 pladienolide D 的 C14-C23 部分，所需步骤是先前所需步骤的一半。
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