Department of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
J Cosmet Dermatol. 2020 May;19(5):1219-1223. doi: 10.1111/jocd.13124. Epub 2019 Sep 6.
Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase-3-like protein 1 (YKL-40) has been found to be implicated in different inflammatory conditions.
We aimed at investigating the role YKL-40 in acne pathogenesis and associated dyslipidemia in acne patients.
PATIENTS/METHODS: This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL-40 in addition to lipid profile were assessed in all studied subjects.
Serum YKL-40 level was significantly elevated in acne patients than healthy controls (P < .001). We also found a significant positive correlations between serum YKL-40, serum TGs, TC, and LDL-C (P value: .022, .001, .017 respectively) while, a significant negative correlation between serum YKL-40 and HDL-c (P value: .036) was detected.
Our study results suggest that YKL-40 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients.
寻常痤疮（AV）是一种炎症性皮肤病，可能与代谢紊乱有关。痤疮中的脂质谱之间的关系尚未广泛研究。几丁质酶-3 样蛋白 1（YKL-40）已被发现与不同的炎症状态有关。
我们旨在研究 YKL-40 在痤疮发病机制中的作用以及痤疮患者相关的血脂异常。
患者/方法：本研究包括 50 例寻常痤疮患者和 30 名匹配的对照组。所有研究对象均评估血清 YKL-40 及血脂谱。
痤疮患者的血清 YKL-40 水平明显高于健康对照组（P<0.001）。我们还发现血清 YKL-40 与血清 TGs、TC 和 LDL-C 呈显著正相关（P 值分别为.022、.001、.017），而与 HDL-c 呈显著负相关（P 值为.036）。
我们的研究结果表明，YKL-40 可能在 AV 的发病机制中起作用。此外，它可以为痤疮患者中观察到的炎症和血脂异常之间提供新的潜在联系。
