Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.
J Cosmet Dermatol. 2020 May;19(5):1105-1109. doi: 10.1111/jocd.13116. Epub 2019 Sep 6.
There is a tremendous demand for dermal rejuvenation with minimal invasiveness and patient downtime.
In this study, we evaluated the performance of nonfractional monopolar radiofrequency for the improvement of photoaged skin texture and wrinkles.
In total, 32 6-week-old female hairless mice were randomized into four groups of eight mice each: (a) healthy control, (b) UVB-exposed, (c) UVB + microneedling, and (d) UVB + microneedle RF. After applying each treatment modality, skin surface was globally investigated and histologically evaluated senile skin change. Immunohistochemistry was tested with the primary antibody to collagen type I and III.
After UVB exposure, the Ra value was significantly increased, leading to clinical development of wrinkles with xerotic scales. Depth and number of wrinkles showed gradual improvement in RF-treated mice. The mean Ra value of the RF-treated group decreased significantly. The RF-treated group showed decreased epidermal thickness, suppression of dermal inflammatory cell infiltration, and increased density of collagen fibers and amount of elastic fibers.
Microneedle RF treatment alleviates photoaged skin texture and wrinkles in this mouse model. To the best of our knowledge, our results provide the first evidence that a nonfractional monopolar microneedle radiofrequency device may contribute to the treatment of UV-damaged skin.
人们对微创且患者恢复期短的皮肤年轻化治疗有巨大需求。
本研究旨在评估非剥脱性单极射频对改善光老化皮肤质地和皱纹的效果。
32 只 6 周龄雌性无毛小鼠随机分为四组，每组 8 只：（a）健康对照组；（b）UVB 暴露组；（c）UVB+微针组；（d）UVB+微针射频组。对每组治疗后的皮肤进行全面观察，并用组织学评估皮肤老化变化。采用 I 型和 III 型胶原蛋白的一抗进行免疫组化检测。
UVB 暴露后，Ra 值显著增加，导致皮肤出现皱纹并伴有干燥鳞屑。经 RF 治疗后，皱纹的深度和数量逐渐改善。RF 治疗组的 Ra 值明显降低。RF 治疗组表皮厚度变薄，真皮炎症细胞浸润减少，胶原纤维密度和弹性纤维含量增加。
微针射频治疗可改善该小鼠模型的光老化皮肤质地和皱纹。据我们所知，我们的研究结果首次提供了证据，表明非剥脱性单极微针射频设备可能有助于治疗 UV 损伤皮肤。
