Hong Ji Yeon, Lee Yoon Hwan, Kim Hyun-Jo, Park Kui Young
Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
CNP Skin Clinic, Asan, Korea.
J Cosmet Dermatol. 2025 Jan;24(1):e16595. doi: 10.1111/jocd.16595. Epub 2024 Oct 7.
Polynucleotide (PN) filler often causes pain and can lead to delivery inaccuracies when applied via intradermal injection using a traditional needle.
To evaluate the efficacy of treatment and the pain during the procedure using conventional needle injection versus a needle-free jet system for intradermal PN filler application.
In this split-face clinical trial, 10 Korean subjects were enrolled. Each subject received an intradermal injection of PN filler on one side of the face and a needle-free jet injection using CureJet on the other side. Assessments included global and 3D skin imaging at each visit. Pain intensity was evaluated using visual analogue scale (VAS) scores during the injection. Additionally, patient satisfaction and adverse events were documented.
Findings revealed that Global Aesthetic Improvement Scale scores and patient satisfaction were significantly higher with the CureJet compared to the needle injection method. VAS scores were notably lower on the CureJet side. Improvements in both pore and wrinkle indices were observed from baseline, with a more pronounced improvement rate on the CureJet side compared to the needle injection side.
Needle-free injection of PN for aging skin was found to be effective in enhancing pore and wrinkle improvement, while reducing associated discomfort.
多核苷酸（PN）填充剂在使用传统针头进行皮内注射时，常常会引起疼痛，并可能导致注射不准确。
评估使用传统针头注射与无针喷射系统进行皮内PN填充剂注射时的治疗效果及操作过程中的疼痛情况。
在这项半脸临床试验中，招募了10名韩国受试者。每位受试者一侧面部接受PN填充剂皮内注射，另一侧面部使用CureJet进行无针喷射注射。每次访视时的评估包括整体和三维皮肤成像。注射过程中使用视觉模拟量表（VAS）评分评估疼痛强度。此外，记录患者满意度和不良事件。
研究结果显示，与针头注射法相比，使用CureJet时全球美学改善量表评分和患者满意度显著更高。CureJet一侧的VAS评分明显更低。从基线观察到毛孔和皱纹指数均有改善，与针头注射侧相比，CureJet一侧的改善率更显著。
发现无针注射PN用于改善老化皮肤在增强毛孔和皱纹改善效果的同时，还能减轻相关不适。
