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[心肌梗死中免疫稳态的多种机制]

[Various mechanisms of immune homeostasis in myocardial infarction].

作者信息

Dobrotina N A, Kopytova T V, Berezina M A

出版信息

Vopr Med Khim. 1988 Nov-Dec;34(6):53-7.

PMID:3149073
Abstract

Dynamic alterations and interrelationships of the patterns of humoral immunity (immunoglobulins and immune complexes) were studied in 77 patients with myocardium infarction and in 23 healthy donors. Stimulation of immunity homeostasis in the patients with acute form of myocardium infarction was manifested as an increase in content of immunoglobulins and immune complexes. Content of immunoglobulin G was distinctly decreased in epistenocardic pericarditis. High rate of correlations was found between the patterns studied in healthy persons (r = 0.7 = 0.85). During the acute period of myocardium infarction disbalance of homeostasis was observed, which was expressed as a decrease in the correlation coefficient down to r = 0.41 = 0.54. An increase in the interrelation and redistribution of the argument-functional parameters were detected in dynamics of the disease.

摘要

对77例心肌梗死患者和23名健康献血者的体液免疫模式(免疫球蛋白和免疫复合物)的动态变化及相互关系进行了研究。急性心肌梗死患者免疫稳态的刺激表现为免疫球蛋白和免疫复合物含量增加。在心包心肌膜炎中,免疫球蛋白G含量明显降低。在健康人身上研究的模式之间发现了高相关性(r = 0.7 = 0.85)。在心肌梗死急性期观察到稳态失衡,表现为相关系数降至r = 0.41 = 0.54。在疾病动态过程中检测到论证功能参数的相互关系增加和重新分布。

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