Seliger E, Schöneich C, Kaltwasser P, Bergleiter R, Buchmann J, Rothe K
Klinik und Poliklinik für Gynäkologie und Geburtshilfe, Martin-Luther-Universität Halle-Wittenberg.
Zentralbl Gynakol. 1988;110(23):1499-506.
Clomiphene in combination with human menopausal gonadotropin (HMG) or HMG alone was used for ovarian stimulation in the IVF program. In 41 cases without embryo transfer (ova could not be obtained or fertilised) 7-8 days after laparoscopy on endometrial biopsy was performed. Serum steroid hormone levels were estimated at the same day and in the time before follicular puncture. Histological classification of the received endometrium and the determination of the kinetic parameters of cytosolic estrogen and progesterone receptors were carried out. A strong correlation exists between histological results and receptor properties. Luteal phase defects are not only connected with a significant decrease of receptor binding capacity but also an increase of the dissociation constants occurs. Clomiphene HMG treatment results in general reduction of binding affinity of the cytosolic estrogen receptor. No correlation was found between the serum hormone levels at day of biopsy and the endometrial histology or receptor parameters on the other hand.
克罗米芬联合人绝经期促性腺激素（HMG）或单独使用HMG用于体外受精（IVF）程序中的卵巢刺激。在41例未进行胚胎移植的病例（无法获取或受精卵子）中，在腹腔镜检查后7 - 8天进行子宫内膜活检。在同一天以及卵泡穿刺前测定血清甾体激素水平。对获取的子宫内膜进行组织学分类，并测定胞质雌激素和孕激素受体的动力学参数。组织学结果与受体特性之间存在强相关性。黄体期缺陷不仅与受体结合能力的显著降低有关，而且解离常数也会增加。克罗米芬 - HMG治疗总体上导致胞质雌激素受体结合亲和力降低。另一方面，活检当天的血清激素水平与子宫内膜组织学或受体参数之间未发现相关性。
