Leroith D, Danovitz G, Trestan S, Spitz I M
J Clin Endocrinol Metab. 1979 Dec;49(6):815-7. doi: 10.1210/jcem-49-6-815.
PRL secretion was evaluated in 14 males with chronic renal failure on long term hemodialysis. Twelve had basal hyperprolactinemia. Ten subjects were challenged with TRH in doses ranging from 200--1000 micrograms. None of them responded to 200 or 500 micrograms TRH, although 2 of 4 subjects tested did respond to 1000 micrograms TRH. In contrast, all 4 subjects challenged with metoclopramide did have PRL responses which were indistinguishable from those of the controls. These results indicate that there is a dissociation in responsiveness to metoclopramide and TRH in chronic renal failure.
对14名长期接受血液透析的慢性肾衰竭男性患者的催乳素（PRL）分泌情况进行了评估。其中12人存在基础高催乳素血症。10名受试者接受了剂量范围为200 - 1000微克的促甲状腺激素释放激素（TRH）激发试验。尽管4名接受测试的受试者中有2名对1000微克TRH有反应，但他们中无人对200微克或500微克TRH产生反应。相比之下，所有4名接受甲氧氯普胺激发试验的受试者均出现了催乳素反应，且与对照组的反应无明显差异。这些结果表明，慢性肾衰竭患者对甲氧氯普胺和促甲状腺激素释放激素的反应性存在分离现象。
