人多能干细胞衍生的心血管细胞：从发育生物学到治疗应用。
Human Pluripotent Stem Cell-Derived Cardiovascular Cells: From Developmental Biology to Therapeutic Applications.
机构信息
McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
BlueRock Therapeutics ULC, Toronto, ON M5G 1L7, Canada.
出版信息
Cell Stem Cell. 2019 Sep 5;25(3):311-327. doi: 10.1016/j.stem.2019.07.010.
Advances in our understanding of cardiovascular development have provided a roadmap for the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types found in the heart. In this Perspective, we review the state of the field in generating and maturing cardiovascular cells from hPSCs based on our fundamental understanding of heart development. We then highlight their applications for studying human heart development, modeling disease-performing drug screening, and cell replacement therapy. With the advancements highlighted here, the promise that hPSCs will deliver new treatments for degenerative and debilitating diseases may soon be fulfilled.
我们对心血管发育的理解的进步为定向分化人类多能干细胞（hPSCs）为心脏中发现的主要细胞类型提供了路线图。在本观点中，我们根据对心脏发育的基本理解，综述了从 hPSCs 生成和成熟心血管细胞的领域现状。然后，我们强调了它们在研究人类心脏发育、疾病模型药物筛选和细胞替代治疗方面的应用。有了这里强调的进展，hPSCs 将为退行性和使人衰弱的疾病带来新疗法的承诺可能很快就会实现。
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