Wickramasinghe L S, Basu S K, Bansal S K
Department of Medicine for the Elderly, District General Hospital, Sunderland.
Age Ageing. 1988 Nov;17(6):388-96. doi: 10.1093/ageing/17.6.388.
Forty-nine patients aged 65-89 years, treated for 6 months-6 years (mean 3.9 years) over a total of 195 patient years, were studied. The efficacy of anticoagulant control or the occurrence of complications or treatment failures did not vary with the age, sex, social status, mobility, visual acuity, domiciliary supervision of medication or the indication for anticoagulation. A significant correlation was observed between the concomitant drug therapy and anticoagulant control (P less than 0.001) but not with the occurrence of complications and treatment failures. Poor anticoagulant control was observed particularly in those receiving drugs known to potentiate warfarin effect and in whom more changes were made to their concomitant drug therapy. Five patients who experienced six non-fatal haemorrhages (two major and four minor) showed poor overall anticoagulant control from the outset (P less than 0.01). The treatment failure rate was 4%.
对49名年龄在65至89岁之间的患者进行了研究，这些患者接受治疗的时间为6个月至6年（平均3.9年），总计195患者年。抗凝控制的效果、并发症的发生情况或治疗失败情况并不随年龄、性别、社会地位、活动能力、视力、药物的居家监督或抗凝指征而变化。观察到伴随药物治疗与抗凝控制之间存在显著相关性（P小于0.001），但与并发症的发生和治疗失败无关。尤其在那些接受已知会增强华法林作用的药物且伴随药物治疗有更多变化的患者中，观察到抗凝控制不佳。5名经历了6次非致命性出血（2次大出血和4次小出血）的患者从一开始就显示出总体抗凝控制不佳（P小于0.01）。治疗失败率为4%。
