KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium.
Cell Calcium. 2019 Nov;83:102076. doi: 10.1016/j.ceca.2019.102076. Epub 2019 Aug 28.
L-asparaginase treatment is used in the clinic to treat acute lymphoblastic leukemia (ALL) patients. Lee et al. (2019, Blood 133:2222-2232) demonstrated that L-asparaginase induces apoptosis by activating inositol 1,4,5-trisphosphate (IP)-induced Ca signaling in a Huntingin-associated protein 1 (HAP1)-dependent manner. Moreover, HAP1 levels inversely correlate with the sensitivity of the ALL cells to L-asparaginase. HAP1 can therefore be used as biomarker for evaluating L-asparaginase resistance.
L-天冬酰胺酶治疗被用于临床治疗急性淋巴细胞白血病（ALL）患者。Lee 等人（2019，Blood 133：2222-2232）证明，L-天冬酰胺酶通过激活肌醇 1,4,5-三磷酸（IP）诱导的 Ca 信号以 Huntingtin 相关蛋白 1（HAP1）依赖性方式诱导细胞凋亡。此外，HAP1 水平与 ALL 细胞对 L-天冬酰胺酶的敏感性呈负相关。因此，HAP1 可以用作评估 L-天冬酰胺酶耐药性的生物标志物。
