铜绿假单胞菌黏液型和非黏液型变体吞噬作用的研究。II. 铜绿假单胞菌黏液型菌株诱导的异源免疫。
Studies on phagocytosis of mucoid and nonmucoid variants of Pseudomonas aeruginosa. II. Induction of heterologous immunity by mucoid strains of P. aeruginosa.
作者信息
Gościniak G, Grzybek-Hryncewicz K
机构信息
Department of Microbiology, Medical Academy, Wroclaw.
出版信息
Arch Immunol Ther Exp (Warsz). 1988;36(2):185-93.
The studies were performed to determine the level of phagocytosis and intracellular killing of mucoid P. aeruginosa strains in normal and monovalent immune sera against: mucoid (anti-OM) and nonmucoid (anti-O) variants and slime extracts (anti-M) of 15 P. aeruginosa strains belonging to 7 immunotypes of Fisher's scheme. Extracellular P. aeruginosa slime was observed to inhibit the process of phagocytosis and intracellular killing of these bacteria. On the other hand, antibodies directed against the extracellular slime neutralized the inhibitory effect of the slime on phagocytosis. Slime of strains of different somatic antigen displayed serological affinity. This was due to cross reactions in phagocytic and agglutination test of mucoid strains in immune sera containing anti-slime antibodies. Strains of the same somatic antigen produced antigenically differentiated slime.
开展这些研究是为了确定在针对15株铜绿假单胞菌的正常血清和单价免疫血清中，黏液型铜绿假单胞菌菌株的吞噬作用水平和细胞内杀伤情况。这15株铜绿假单胞菌属于费舍尔分类法的7种免疫型，其黏液型（抗OM）和非黏液型（抗O）变体以及黏液提取物（抗M）。观察到细胞外铜绿假单胞菌黏液会抑制这些细菌的吞噬作用和细胞内杀伤过程。另一方面，针对细胞外黏液的抗体可中和黏液对吞噬作用的抑制效果。不同菌体抗原菌株的黏液表现出血清学亲和力。这是由于在含有抗黏液抗体的免疫血清中，黏液型菌株在吞噬试验和凝集试验中出现了交叉反应。相同菌体抗原的菌株产生了抗原性不同的黏液。
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