Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.
Institute for Biomaterials Research and Development, Kyungpook National University, Daegu 41940, Korea.
Int J Mol Sci. 2019 Sep 5;20(18):4364. doi: 10.3390/ijms20184364.
Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey's fiber anchorages for state-of-the-art periodontal tissue engineering.
目前，已经开发出了多种组织工程策略，用于进行多种组织的再生和整体结构的形成，以及在肌肉骨骼复合体中单组织的形成。特别是，牙周组织或牙齿支持结构的再生仍然具有挑战性，需要在时空上分隔聚己内酯（PCL）-牙骨质构建体，形成具有微米级界面的、沿牙根表面具有最佳尺寸的整体组织（或牙骨质）形成物，以及具有特定工程牙周韧带（PDL）方向的构建体。在这里，我们讨论了当前用于时空控制 PDL 特定角度取向的先进方法，以及用于最先进的牙周组织工程的在牙根表面再生具有 Sharpey 纤维锚固的牙骨质层的方法。
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