Université Lyon, VetAgro Sup, Service d'Anesthésie, Marcy l'Etoile, 69280, France.
Université Lyon, VetAgro Sup, Service d'imagerie médicale, Marcy l'Etoile, 69280, France.
Vet J. 2019 Sep;251:105346. doi: 10.1016/j.tvjl.2019.105346. Epub 2019 Jul 27.
The aim of this study was to compare the sedative and cardiovascular effects of dexmedetomidine (DEX) administrated via intranasal (IN) and intramuscular (IM) routes. This masked, randomised, crossover study used six male beagle dogs, receiving 0.02 mg/kg dexmedetomidine either IN (DEX-IN) or IM (DEX-IM), and an equal volume of saline by the alternative route. Dexmedetomidine plasma concentration was measured before (TB) and at time points (T) 2, 5, 10, 15, 30, 45, 60, 90 and 120 min after drug administration (T0). Physiological variables, sedation scores and sedation times were recorded until recovery. Echocardiography was performed at TB and between T20-T40. Repeated data over time were analysed using a Scheirer-Ray-Hare test. Other data were compared using a Wilcoxon or Student's t test. Times from T0 to sternal position and from lateral to sternal position were longer for DEX-IN than DEX-IM (P = 0.018 and P = 0.009, respectively). Time from sternal to standing position was shorter for DEX-IN than DEX-IM (P = 0.03). Dexmedetomidine plasma concentrations were significantly lower for DEX-IN than DEX-IM from T10 to T120. Heart rate was significantly lower for DEX-IM than DEX-IN from T5 to T20. Echocardiography showed a decrease in systolic function and calculated cardiac output in DEX-IM as compared to baseline. The DEX concentration-sedation curve for DEX-IN as compared to DEX-IM was leftward shifted, whereas the IN and IM DEX concentration-variation-in-heart-rate curves overlapped. Although reaching lower plasma concentrations, IN dexmedetomidine produced similar sedation to IM dexmedetomidine without affecting cardiovascular function.
本研究旨在比较经鼻（IN）和肌肉内（IM）途径给予右美托咪定（DEX）的镇静和心血管效应。这项双盲、随机、交叉研究使用了 6 只雄性比格犬，分别接受 0.02mg/kg 的右美托咪定经 IN（DEX-IN）或 IM（DEX-IM）途径给药，以及通过另一种途径给予等量的生理盐水。在药物给药前（TB）和给药后 2、5、10、15、30、45、60、90 和 120 分钟（T0）测量右美托咪定的血浆浓度。记录生理变量、镇静评分和镇静时间，直到恢复。在 TB 和 T20-T40 之间进行超声心动图检查。使用 Scheirer-Ray-Hare 检验分析随时间重复的数据。使用 Wilcoxon 或学生 t 检验比较其他数据。从 T0 到胸骨位置以及从侧位到胸骨位置的时间对于 DEX-IN 比 DEX-IM 更长（P=0.018 和 P=0.009）。从胸骨到站立位置的时间对于 DEX-IN 比 DEX-IM 更短（P=0.03）。从 T10 到 T120，DEX-IN 的右美托咪定血浆浓度明显低于 DEX-IM。从 T5 到 T20，DEX-IM 的心率明显低于 DEX-IN。与基线相比，DEX-IM 的超声心动图显示收缩功能和计算的心输出量下降。与 DEX-IM 相比，DEX-IN 的 DEX 浓度-镇静曲线向左移位，而 IN 和 IM DEX 浓度-心率变化曲线重叠。尽管达到较低的血浆浓度，但 IN 右美托咪定产生与 IM 右美托咪定相似的镇静作用，而不影响心血管功能。
