van Egmond H P, Wagstaffe P J
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
J Assoc Off Anal Chem. 1988 Nov-Dec;71(6):1180-2.
The development of a full cream milk powder reference material, certified for its aflatoxin M1 content (target concentration: 0.1 microgram/kg), is described. The material (RM 283) was prepared and certified within the Reference Material Programme of the Community Bureau of Reference, along with other members of a series of milk powder reference materials. Homogeneity, evaluated by determining the aflatoxin M1 content of 30 units, was found to be acceptable (coefficient of variation of analysis results: 9.1%); stability has been demonstrated in a long-term study. The certification exercise involved 7 laboratories. Calibration, control of recoveries, blank values, and independence of the replicate measurements were emphasized. All sets of results of the certification exercise were accepted for statistical evaluation. A certified value for the aflatoxin M1 content: 0.09(+0.04)(-0.02) micrograms/kg was derived. The certification of RM 283 completes the series of 4 milk powder reference materials having certified aflatoxin M1 contents.
本文描述了一种全脂奶粉参考物质的研制情况，该参考物质已通过黄曲霉毒素M1含量认证（目标浓度：0.1微克/千克）。该物质（RM 283）是在欧洲共同体标准局参考物质计划内制备并认证的，它是一系列奶粉参考物质中的一员。通过测定30个单元的黄曲霉毒素M1含量来评估其均匀性，结果表明均匀性良好（分析结果的变异系数为9.1%）；通过长期研究证明了其稳定性。认证工作由7个实验室参与。强调了校准、回收率控制、空白值以及重复测量的独立性。认证工作的所有结果集都被接受用于统计评估。得出黄曲霉毒素M1含量的认证值为：0.09（+0.04）（-0.02）微克/千克。RM 283的认证完成了4种具有黄曲霉毒素M1含量认证的奶粉参考物质系列。
