School of Chemistry and Chemical Engineering, Xuchang University, 88 Bayi Road, Xuchang, 461000, Henan, People's Republic of China.
School of Information Engineering, Xuchang University, 88 Bayi Road, Xuchang, 461000, Henan, People's Republic of China.
J Nat Med. 2020 Jan;74(1):269-274. doi: 10.1007/s11418-019-01359-8. Epub 2019 Sep 6.
One novel neoligan glucoside, Ginkgoside B (1), and one new glucose ester, 6-O-(4-hydroxyhydrocinnamoyl)-D-glucopyranose (2), along with nine known compounds (3-11) were isolated from the ethanol extract of Ginkgo biloba leaves. Their structures were elucidated by combination of spectroscopic analyses and alkaline methanolysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction. All the isolated compounds were evaluated for their cytotoxicity activities, and compound 11 exhibited IC values of 36.20 and 58.95 μM against 5637 and HeLa cell lines, respectively.
从银杏叶乙醇提取物中分离得到 1 个新的黄烷醇糖苷银杏苷 B（1）和 1 个新的葡萄糖酯 6-O-(4-羟基肉桂酰基)-D-吡喃葡萄糖（2），以及 9 个已知化合物（3-11）。通过光谱分析和碱性甲醇解组合确定了它们的结构。通过单晶 X 射线衍射确定了化合物 1 的绝对构型。所有分离得到的化合物均进行了细胞毒性活性评价，化合物 11 对 5637 和 HeLa 细胞系的 IC 值分别为 36.20 和 58.95 μM。
