Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia.
Discipline of Biomedicine, College of Public Health, Medicine and Veterinary Sciences, James Cook University, Townsville, QLD, Australia.
Adv Exp Med Biol. 2019;1178:77-101. doi: 10.1007/978-3-030-25650-0_5.
This chapter reviews the efficacy of the ketogenic diet in a variety of neurodegenerative, neurodevelopmental and metabolic conditions throughout different stages of life. It describes conditions affecting children, metabolic disorders in adults and disorderrs affecting the elderly. We have focused on application of the ketogenic diet in clinical studies and in preclinical models and discuss the benefits and negative aspects of the diet. Finally, we highlight the need for further research in this area with a view of discovering novel mechanistic targets of the ketogenic diet, as a means of maximising the potential benefits/risks ratio.
本章综述了生酮饮食在生命不同阶段的各种神经退行性、神经发育性和代谢性疾病中的疗效。它描述了影响儿童的疾病、成人代谢紊乱和影响老年人的疾病。我们专注于生酮饮食在临床研究和临床前模型中的应用，并讨论了该饮食的益处和负面影响。最后，我们强调需要进一步研究这一领域，以发现生酮饮食的新的机制靶点，从而最大限度地提高潜在的益处/风险比。
