Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2019;1178:113-127. doi: 10.1007/978-3-030-25650-0_7.
Both morbidity and mortality due to cardiovascular diseases (CVDs) elevate with age. The elevated prevalence of cardiovascular risk factors with age and cardiovascular aging contribute to the relationship between aging and CVDs. Dietary restriction (DR) consisting of calorie restriction (CR) and alternate-day fasting (ADF) is an approved nutritional intervention and shows anti-aging impacts. Recent studies demonstrate that DR makes an active defense response in stressful states. At the core of this response are cardiovascular protective signals, which consist of the mammalian target of rapamycin (mTOR), AMP-activated kinase, sirtuins and endothelial nitric oxide synthase. These make a network with positive and negative feedback regulation. Hence, DR is a hopeful intervention for controlling cardiovascular aging and managing individuals with CVDs.
由于心血管疾病（CVDs），发病率和死亡率都随着年龄的增长而升高。心血管危险因素的高发率和心血管衰老随着年龄的增长而增加，这导致了衰老和 CVDs 之间的关系。饮食限制（DR）包括热量限制（CR）和隔日禁食（ADF），是一种被认可的营养干预措施，并显示出抗衰老的影响。最近的研究表明，DR 在应激状态下做出积极的防御反应。这种反应的核心是心血管保护信号，包括雷帕霉素靶蛋白（mTOR）、AMP 激活的蛋白激酶、沉默调节蛋白和内皮型一氧化氮合酶。这些信号形成了一个具有正、负反馈调节的网络。因此，DR 是控制心血管衰老和管理 CVDs 患者的一种有希望的干预措施。
