年龄因素对大鼠离体心肌细胞和线粒体呼吸控制的影响
Influence of Age Factor on Respiratory Control of Isolated Cardiomyocytes and Mitochondria in Rats.
作者信息
Tsapko L P, Afanas'ev S A
机构信息
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
出版信息
Bull Exp Biol Med. 2019 Aug;167(4):452-454. doi: 10.1007/s10517-019-04547-4. Epub 2019 Sep 6.
PMID:31493260
Abstract
We studied the peculiarities of oxidative and substrate phosphorylation in isolated cardiomyocytes and myocardial mitochondria in 2- and 15-month-old rats. It was shown that age factor reduces the degree of oxidation and phosphorylation coupling both in cardiomyocytes and in mitochondria, which was associated with the decrease in the rate of consumption of energy resources.
摘要
我们研究了2月龄和15月龄大鼠分离的心肌细胞和心肌线粒体中氧化磷酸化和底物磷酸化的特点。结果表明，年龄因素会降低心肌细胞和线粒体中氧化与磷酸化的偶联程度，这与能量资源消耗速率的降低有关。
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