McKnight J A, Hird F J
Comp Biochem Physiol B. 1986;85(2):289-94. doi: 10.1016/0305-0491(86)90002-7.
The oxidation by mitochondria of various rat tissues of proline, pyrroline-5-carboxylate (P5C) and a number of aldehydes has been studied and ADP/O ratios determined for liver mitochondria. High oxidative activity for proline and P5C was found only in the liver and kidney. During the oxidation by liver and kidney mitochondria of proline and P5C; glutamate, ammonia, aspartate and some ornithine accumulated, thus suggesting that proline may normally be converted to ornithine by mitochondria. The oxidation of P5C (glutamic acid semialdehyde) by a mitochondrial dehydrogenase may be the same enzyme that oxidizes succinic acid semi-aldehyde but different from that oxidizing acetaldehyde.
已对大鼠各种组织中线粒体对脯氨酸、吡咯啉 - 5 - 羧酸（P5C）及多种醛类的氧化作用进行了研究，并测定了肝线粒体的ADP/O比值。仅在肝脏和肾脏中发现脯氨酸和P5C具有高氧化活性。在肝脏和肾脏线粒体氧化脯氨酸和P5C的过程中，谷氨酸、氨、天冬氨酸和一些鸟氨酸会积累，这表明脯氨酸通常可能由线粒体转化为鸟氨酸。线粒体脱氢酶对P5C（谷氨酸半醛）的氧化作用可能与氧化琥珀酸半醛的酶相同，但与氧化乙醛的酶不同。
