Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China; Clinic Department, Hengyang Medical College, University of South China, Hengyang 421001, PR China.
Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China.
Clin Chim Acta. 2019 Dec;499:118-122. doi: 10.1016/j.cca.2019.09.002. Epub 2019 Sep 4.
Vascular calcification is associated with adverse cardiovascular events that increase the risk of cardiovascular death. Unfortunately, the pathogenesis of vascular calcification is complex and incompletely understood. As important intercellular signaling molecules, the role of extracellular vesicles (EVs) in vascular calcification has attracted wide attention in recent years. This review will briefly describe the role of EVs (mainly including exosomes and microvesicles) in the process of vascular wall calcification focusing on the specific mechanisms of smooth muscle cell (SMC) differentiation and calcium-phosphorus balance to illustrate the relationship between EVs and vascular calcification. It is likely that EVs may be prognostic markers in some cardiovascular diseases and have potential therapeutic potential.
血管钙化与心血管不良事件相关，增加心血管死亡风险。不幸的是，血管钙化的发病机制复杂，尚未完全阐明。细胞外囊泡（EVs）作为重要的细胞间信号分子，近年来在血管钙化过程中的作用受到广泛关注。本文将简要描述 EVs（主要包括外泌体和微泡）在血管壁钙化过程中的作用，重点阐述平滑肌细胞（SMC）分化和钙磷平衡的具体机制，阐明 EVs 与血管钙化的关系。EVs 可能成为某些心血管疾病的预后标志物，并具有潜在的治疗潜力。
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