Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei City 11031, Taiwan.
Graduate Institute of Mind Brain and Consciousness, Taipei Medical University, Taipei City 11031, Taiwan.
Life Sci. 2019 Oct 15;235:116835. doi: 10.1016/j.lfs.2019.116835. Epub 2019 Sep 4.
Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a critical role in the recovery of muscle injury induced by exercise. The current study evaluated the effect of sleep deprivation on the recovery of muscle injury induced by high-intensity exercise in a mouse model. In this study, 28 mice were randomly assigned to four groups (N = 7): control (Control), exercise (EX), sleep deprivation (SD), and sleep deprivation with exercise (EX+SD). The mice from the EX and EX+SD groups were subjected to high-intensity swimming. The results showed that 72-h sleep deprivation increased food intake and reduced body weight. However, the manipulation of 8-week exercise and/or 72-h sleep deprivation did not have any effect in the elevated plus maze task and tail suspension test. Interestingly, the EX+SD group exhibited improved memory performance in the Morris water maze and impaired motor activity in the open field test. According to the TNF-α level and aspartate aminotransferase (AST), and creatine phosphokinase (CK) activities, only the EX+SD group exhibited muscle impairment. Overall, high-intensity exercise may cause muscle injury, and adequate sleep can recover muscle damage. However, sleep deprivation reduces protein synthesis, which decreases the ability to restore muscle damage and aggravates the harmful effect of high-intensity exercise.
睡眠对于提高运动员的表现和他们的昼夜节律至关重要，但由于运动员参加多项比赛，他们的睡眠模式可能会受到干扰。此外，密集的训练计划会导致运动员肌肉疼痛和心理压力，从而导致睡眠不足。睡眠在运动引起的肌肉损伤恢复中也起着至关重要的作用。本研究评估了睡眠剥夺对高强度运动诱导的小鼠模型中肌肉损伤恢复的影响。在这项研究中，28 只小鼠被随机分为四组（N=7）：对照组（Control）、运动组（EX）、睡眠剥夺组（SD）和运动和睡眠剥夺组（EX+SD）。EX 和 EX+SD 组的小鼠进行高强度游泳。结果表明，72 小时的睡眠剥夺会增加食物摄入并降低体重。然而，8 周的运动和/或 72 小时的睡眠剥夺操作对高架十字迷宫和悬尾试验没有任何影响。有趣的是，EX+SD 组在 Morris 水迷宫中表现出记忆能力提高，而在旷场试验中运动能力受损。根据 TNF-α 水平以及天冬氨酸氨基转移酶（AST）和肌酸磷酸激酶（CK）活性，只有 EX+SD 组表现出肌肉损伤。总的来说，高强度运动可能导致肌肉损伤，充足的睡眠可以恢复肌肉损伤。然而，睡眠剥夺会降低蛋白质合成，从而降低恢复肌肉损伤的能力，并加剧高强度运动的有害影响。
