School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM Penang, Malaysia; Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, P.M.B. 2346, Nigeria.
School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM Penang, Malaysia.
Int J Pharm. 2019 Oct 30;570:118659. doi: 10.1016/j.ijpharm.2019.118659. Epub 2019 Sep 4.
This study aimed to develop a dual action, namely anti-inflammatory and antimicrobial, nanogels (NG) for the treatment of periodontitis using triclosan (TCS) and flurbiprofen (FLB). Triclosan, an antimicrobial drug, was prepared as nanoparticles (NPs) using poly-ε-caprolactone (PCL), while flurbiprofen, an anti-inflammatory drug, was directly loaded in a chitosan (CS) based hydrogel. The entwinement of both NPs and hydrogel loaded systems resulted in the NG. The characterisation data confirmed that the developed formulation consists of nanosized spherical structures and displays pH-dependent swelling/erosion and temperature-responsiveness. Besides, the NG exhibited adequate bioadhesiveness using the chicken pouch model and displayed antibacterial activity through the agar plate method. An in-vivo study of the NG on experimental periodontitis (EP) rats confirmed the dual antibacterial and anti-inflammatory effects which revealed an excellent therapeutic outcome. In conclusion, a dual action NG was successfully developed and proved to have superior therapeutic effects in comparison to physical mixtures of the individual drugs.
本研究旨在开发一种具有双重作用的纳米凝胶（NG），用于治疗牙周炎，该纳米凝胶使用三氯生（TCS）和氟比洛芬（FLB）作为抗炎和抗菌药物。三氯生是一种抗菌药物，使用聚己内酯（PCL）制备成纳米颗粒（NPs），而氟比洛芬是一种抗炎药物，直接负载在壳聚糖（CS）水凝胶中。将这两种 NPs 和水凝胶负载系统缠绕在一起形成 NG。特性数据证实，所开发的配方由纳米级球形结构组成，并表现出 pH 依赖性溶胀/侵蚀和温度响应性。此外，NG 在鸡袋模型中显示出足够的生物粘附性，并通过琼脂平板法显示出抗菌活性。NG 对实验性牙周炎（EP）大鼠的体内研究证实了其双重抗菌和抗炎作用，这显示出了极好的治疗效果。总之，成功开发了一种具有双重作用的 NG，与两种药物的物理混合物相比，其具有更优越的治疗效果。
