Department of Experimental Medicine, University of Study of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Precision Medicine, University of Study of Campania "Luigi Vanvitelli", Naples, Italy.
Microb Pathog. 2019 Nov;136:103719. doi: 10.1016/j.micpath.2019.103719. Epub 2019 Sep 5.
Outer membrane vesicles (OMVs) are potent virulence factors, naturally secreted by gram-negative bacteria. Since Klebsiella pneumoniae has emerged as an important nosocomial pathogen, because of resistance to a wide spectrum of antibiotics, it is crucial to investigate its pathogenetic mechanism microorganism secretes outer membrane vesicles (OMVs), but the pathogenesis of Klebsiella pneumoniae as it relates to OMVs has not been well elucidated. In this study we focused on the isolation, characterization and evaluation of the virulence potential of OMVs obtained from Klebsiella pneumoniae. Our data demonstrate that Klebsiella pneumoniae OMVs are important secretory nanocomplexes that elicit a potent inflammatory response. Since OMVs are clearly involved in the pathogenesis of this bacterium during infection, further studies are required to determine whether they could be future targets for novel therapy and potential vaccine against Klebsiella pneumoniae.
外膜囊泡（OMVs）是革兰氏阴性细菌天然分泌的强效毒力因子。由于肺炎克雷伯菌已成为一种重要的医院获得性病原体，由于对广谱抗生素的耐药性，因此研究其微生物分泌的外膜囊泡（OMVs）的发病机制至关重要，但肺炎克雷伯菌与 OMVs 相关的发病机制尚未得到很好的阐明。在这项研究中，我们专注于从肺炎克雷伯菌中分离、表征和评估 OMVs 的毒力潜力。我们的数据表明，肺炎克雷伯菌 OMVs 是重要的分泌纳米复合物，可引发强烈的炎症反应。由于 OMVs 在感染过程中显然参与了这种细菌的发病机制，因此需要进一步研究以确定它们是否可以成为针对肺炎克雷伯菌的新型治疗和潜在疫苗的未来靶标。
