Kondo E, Kanai K
Department of Cellular Immunology, National Institute of Health, Tokyo.
Jpn J Med Sci Biol. 1988 Apr;41(2):37-47. doi: 10.7883/yoken1952.41.37.
Mice were infected intravenously with a streptomycin (SM)-dependent strain of tubercle bacilli which had been starved of the antibiotic. The inoculum persisted in the spleen for a fairly long period, especially keeping almost the initial level of viable counts in the first few weeks. Isoniazid (INH) administration exerted little effect on such fate of the infection at a bactericidal dose to the same strain multiplying under the supply of SM. Rifampicin (RFP) was, however, highly effective in either case. Similar results were obtained in the corresponding in vitro experiments. The data suggest that this animal model is a convenient system for screening drugs effective on the dormant tuberculous infection.
用一株已停用抗生素的链霉素（SM）依赖型结核杆菌静脉感染小鼠。接种物在脾脏中持续存在相当长一段时间，尤其是在最初几周内几乎保持初始活菌数水平。在对在SM供应下繁殖的同一菌株具有杀菌剂量的情况下，给予异烟肼（INH）对这种感染的命运几乎没有影响。然而，利福平（RFP）在两种情况下都非常有效。在相应的体外实验中也得到了类似的结果。数据表明，这种动物模型是筛选对潜伏性结核感染有效的药物的便利系统。
