PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Growth, Exercise, Nutrition and Development Research Group, University of Zaragoza, Zaragoza, Spain.
Pediatr Res. 2020 Jan;87(1):42-47. doi: 10.1038/s41390-019-0572-8. Epub 2019 Sep 7.
To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.
Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry.
IL-6 (β = -0.136) and VEGF (β = -0.099) were associated with TBLH BMC, while TNF-α (β = -0.345) and IL-1β (β = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = -0.152) and TNF-α with LS BMC (β = -0.491) in the low-fitness group, while no association was found in the high-fitness group.
IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass.
探讨哪些炎症标志物与骨量相关，以及这种相关性是否因超重/肥胖儿童的肌肉健康状况而异。
对 55 名 8-11 岁儿童的血浆白细胞介素-1β（IL-1β）、IL-6、肿瘤坏死因子-α（TNF-α）、表皮生长因子、血管内皮生长因子 A（VEGF）和 C 反应蛋白进行了分析。计算了肌肉健康评分。使用双能 X 射线吸收法评估全身（头部除外）和腰椎的骨矿物质含量（BMC）。
IL-6（β=-0.136）和 VEGF（β=-0.099）与 TBLH BMC 相关，而 TNF-α（β=-0.345）和 IL-1β（β=0.212）与 LS BMC 相关（P<0.05）。肌肉健康的交互作用效应显示 VEGF 与 TBLH BMC 之间的关联（P=0.122）和 TNF-α与 LS BMC 之间的关联（P=0.057）存在趋势。按肌肉健康水平进行的分层分析显示，在低肌肉健康组中，VEGF 与 TBLH BMC 呈负相关（β=-0.152），TNF-α与 LS BMC 呈负相关（β=-0.491），而在高肌肉健康组中则无相关性。
IL-6、VEGF、TNF-α 和 IL-1β与骨量显著相关。较高的肌肉健康水平可能会减弱高 VEGF 和 TNF-α对骨量的不利影响。
