IEEE Trans Ultrason Ferroelectr Freq Control. 2020 Jan;67(1):131-135. doi: 10.1109/TUFFC.2019.2939190. Epub 2019 Sep 3.
In this study, we reported an acoustic wave resonator for temperature monitorable kinetic analysis of human blood coagulation. The resonator is operated in both Lamb wave mode at 860 MHz and Rayleigh wave mode at 444 MHz. The electrical parameter variation of the resonator induced by the increased plasma viscosity can be used to monitor the coagulation process. The Lamb mode of the resonator is sensitive to both plasma viscosity and plasma temperature, while the Rayleigh mode responds only to the temperature which is not affected by viscosity. These unique characteristics of the two modes are due to different spatial distributions of the acoustic energy. Taking advantage of the aforementioned features, an acoustic wave resonator to study the human blood coagulation is designed to simultaneously monitor the temperature and plasma viscosity. The coagulation time and plasma temperature were provided by fitting the time-frequency curves. Our design holds great promise for biological reaction monitoring with possible temperature changes.
在这项研究中，我们报告了一种声波谐振器，用于可监测温度的人体血液凝固动力学分析。该谐振器在 860MHz 的兰姆波模式和 444MHz 的瑞利波模式下运行。谐振器的电参数变化由增加的等离子体粘度引起，可用于监测凝固过程。谐振器的兰姆波模式对等离子体粘度和等离子体温度都很敏感，而瑞利波模式仅响应温度，不受粘度影响。这两种模式的独特特性是由于声能量的不同空间分布。利用上述特征，设计了一种声波谐振器来研究人体血液凝固，以同时监测温度和等离子体粘度。凝血时间和血浆温度通过拟合时频曲线提供。我们的设计在可能发生温度变化的生物反应监测方面具有很大的应用前景。
