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桥本脑病:谵妄的罕见病因。

Hashimoto's encephalopathy: a rare cause of delirium.

作者信息

Ogbebor Osakpolor, Patel Kavya

机构信息

Internal Medicine, Saint Peter's University Hospital, New Brunswick, New Jersey, USA.

出版信息

BMJ Case Rep. 2019 Sep 6;12(9):e230118. doi: 10.1136/bcr-2019-230118.

Abstract

Cognitive impairment is a frequent presentation of patients who come to the hospital. We report a case of a patient who presents with a common symptom, however, with a rare disease. This is an 84-year-old woman with a history of hypertension and atrial fibrillation who was reported to have confusion of 3 weeks. Investigations, including a complete blood count, MRI imaging of the brain, cerebrospinal fluid analysis and paraneoplastic screen, were all negative. Of note, thyroid peroxidase antibody was elevated. She did not have a history of thyroid disease. Following this, an assessment of Hashimoto encephalopathy was made. She was started on steroids and she showed remarkable recovery within 2 months, therefore, confirming the diagnosis. This case report emphasises the need to consider Hashimoto's encephalopathy as a differential for delirium especially when other common aetiologies have been ruled out.

摘要

认知障碍是前来医院就诊患者的常见症状。我们报告一例患者,其表现为常见症状,但患有罕见疾病。这是一位84岁女性,有高血压和心房颤动病史,据报告出现了3周的意识模糊。包括全血细胞计数、脑部MRI成像、脑脊液分析和副肿瘤筛查在内的检查均为阴性。值得注意的是,甲状腺过氧化物酶抗体升高。她既往无甲状腺疾病史。在此之后,对桥本脑病进行了评估。她开始使用类固醇治疗,2个月内病情显著好转,从而确诊。本病例报告强调,尤其是在排除其他常见病因后,需要将桥本脑病作为谵妄的鉴别诊断之一。

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Hashimoto's encephalopathy: a rare cause of delirium.桥本脑病:谵妄的罕见病因。
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本文引用的文献

3
Hashimoto encephalopathy: literature review.桥本脑病:文献综述
Acta Neurol Scand. 2017 Mar;135(3):285-290. doi: 10.1111/ane.12618. Epub 2016 Jun 20.
6
Hashimoto encephalopathy: syndrome or myth?桥本脑病:综合征还是虚构之事?
Arch Neurol. 2003 Feb;60(2):164-71. doi: 10.1001/archneur.60.2.164.
7
Hashimoto's encephalopathy responding to plasmapheresis.对血浆置换有反应的桥本脑病。
J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):132. doi: 10.1136/jnnp.70.1.132.

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