Gut I, Vodicka P, Cikrt M, Sapota A, Kavan I
Institute of Hygiene and Epidemiology, Praha, Czechoslovakia.
Arch Toxicol. 1988;62(5):346-50. doi: 10.1007/BF00293621.
The fate of (14C)-2-ethylhexyl acrylate was studied in adult male Wistar rats given an intravenous (i.v.) or intraperitoneal (i.p.) injection of 10 mg/kg (0.054 mmol/kg). The elimination of radioactivity from blood was bi-exponential, irrespective of the route of (14C)-2-EHA administration or the age (weight) of the rats. The first phase half-lives after i.v. and i.p. administration in 4-month-old rats were 30 and 60 min, in 7-month-old rats 115 and 130 min, respectively. The corresponding values for the slow-phase were 5 and 6 h, and 14 and 14 h. Elimination of the radioactivity from tissues followed a pattern similar to that seen for blood. More than half of the administered radioactivity was exhaled as carbon dioxide. Exhalation of unchanged (14C)-2-EHA accounted for only 0.05% (i.v.) or 0.3% (i.p.) of the initial dose of radioactivity. The radioactivity excreted in the urine within the first 24 h post-treatment accounted for 7% (i.p.) or 14% (i.v.) of the initial dose, and only 2% was excreted as thioethers.
在成年雄性Wistar大鼠中，通过静脉注射（i.v.）或腹腔注射（i.p.）给予10 mg/kg（0.054 mmol/kg）的（14C）-丙烯酸2-乙基己酯，研究其命运。无论（14C）-2-EHA的给药途径或大鼠的年龄（体重）如何，血液中放射性的消除都是双指数的。在4个月大的大鼠中，静脉注射和腹腔注射后的第一阶段半衰期分别为30分钟和60分钟，在7个月大的大鼠中分别为115分钟和130分钟。慢相的相应值分别为5小时和6小时，以及14小时和14小时。组织中放射性的消除模式与血液中的相似。超过一半的给药放射性以二氧化碳形式呼出。未变化的（14C）-2-EHA的呼出仅占初始放射性剂量的0.05%（静脉注射）或0.3%（腹腔注射）。治疗后24小时内尿液中排出的放射性占初始剂量的7%（腹腔注射）或14%（静脉注射），只有2%以硫醚形式排出。
