[2,3-14C]-甲基丙烯酸甲酯和[2,3-14C]-2-乙基己酯在雄性Wistar白化大鼠体内的处置情况。

The disposition of [2,3-14C]-methyl and [2,3-14C]-2-ethylhexyl acrylate in male Wistar albino rats.

作者信息

Sapota A

机构信息

Department of Metabolism of Toxic Substances, Institute of Occupational Medicine, Lódź, Poland.

出版信息

Arch Toxicol. 1988;62(2-3):181-4. doi: 10.1007/BF00570137.

DOI:10.1007/BF00570137

PMID:3196152

Abstract

The disposition of methyl [2,3-14C]-acrylate (MA) and 2-ethylhexyl [2,3-14C]-acrylate (EHA) following intraperitoneal and oral administration to rats has been studied. The 14C found in the tissues was mainly associated with liver, kidneys and lungs. Loss of 14C from these tissues occurred fairly rapidly, excluding the rats given EHA intraperitoneally. Most of the administered acrylates underwent rapid metabolism and excretion with expired air (more than 50% of the dose and urine (10-50% of the dose). Significant differences in the rates of 14C loss from tissues and excretion occurred after intrapritoneal administration of MA and EHA. A possible cumulation of EHA in the organism was suggested.

摘要

对大鼠腹腔注射和口服[2,3 - 14C] - 丙烯酸甲酯（MA）和[2,3 - 14C] - 2 - 乙基己酯（EHA）后的处置情况进行了研究。组织中发现的14C主要与肝脏、肾脏和肺有关。除腹腔注射EHA的大鼠外，这些组织中14C的损失相当迅速。大部分给药的丙烯酸酯经历了快速代谢并通过呼出气体（超过剂量的50%）和尿液（剂量的10 - 50%）排泄。腹腔注射MA和EHA后，组织中14C损失率和排泄率存在显著差异。提示EHA可能在生物体内蓄积。