癫痫患儿唾液中卡马西平和卡马西平-10,11-环氧化物浓度的24小时变化情况。

The 24 hour variation of salivary carbamazepine and carbamazepine-10,11-epoxide concentrations in children with epilepsy.

作者信息

Bäckman E, Dahlström G, Eeg-Olofsson O, Bertler A

机构信息

Department of Pediatrics, University Hospital, Linköping, Sweden.

出版信息

Pediatr Neurol. 1987 Nov-Dec;3(6):327-30. doi: 10.1016/0887-8994(87)90002-6.

DOI:10.1016/0887-8994(87)90002-6

PMID:3149473

Abstract

Variations in carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-EP) concentrations were measured in saliva over 24 hours in 33 children with complex partial seizures and/or generalized tonic-clonic seizures; all patients received CBZ as monotherapy. CBZ varied between 37-104% and CBZ-EP varied between 26-119%. One venous blood sample was obtained simultaneously with the first saliva sample before the morning dose of CBZ. The free fraction of plasma CBZ was 25.5%. Medication side effects are most likely to appear within 3-4 hours of drug intake; therefore, it is advisable to take another sample in children demonstrating time-related side effects. A controlled release formulation of CBZ should minimize the fluctuations of salivary drug levels of CBZ and CBZ-EP.

摘要

在33名患有复杂部分性癫痫发作和/或全身性强直阵挛性癫痫发作的儿童中，在24小时内测量了唾液中卡马西平（CBZ）和卡马西平-10,11-环氧化物（CBZ-EP）的浓度变化；所有患者均接受CBZ单一疗法治疗。CBZ的变化范围在37%-104%之间，CBZ-EP的变化范围在26%-119%之间。在早晨服用CBZ剂量之前，与第一份唾液样本同时采集了一份静脉血样本。血浆CBZ的游离分数为25.5%。药物副作用最有可能在服药后3-4小时内出现；因此，对于出现与时间相关副作用的儿童，建议再采集一份样本。CBZ的控释制剂应能最大限度地减少CBZ和CBZ-EP唾液药物水平的波动。