Theodore W H, Narang P K, Holmes M D, Reeves P, Nice F J
Clinical Epilepsy Section, National Institute for Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Ann Neurol. 1989 Feb;25(2):194-6. doi: 10.1002/ana.410250215.
We studied the relation of plasma levels of carbamazepine (CBZ) and carbamazepine 10,11 epoxide (CBZ-E), and their ratio to drug toxicity and seizure control in 7 patients with complex partial seizures. CBZ-E/CBZ increased with increasing CBZ levels and was higher when patients were taking phenytoin or valproic acid. There were weak correlations between CBZ, CBZ-E levels, toxicity scores, and seizure control when patients were taking CBZ alone, but not when other drugs were given as well. There were no significant differences in the correlation with toxicity score or seizure frequency between CBZ, CBZ-E, or their sum. Measurement of CBZ-E levels did not provide additional information useful for monitoring clinical response to CBZ therapy.
我们研究了7例复杂部分性癫痫患者血浆中卡马西平（CBZ）和卡马西平10,11-环氧化物（CBZ-E）的水平及其比值与药物毒性和癫痫控制之间的关系。CBZ-E/CBZ比值随CBZ水平升高而增加，且在患者服用苯妥英或丙戊酸时更高。当患者仅服用CBZ时，CBZ、CBZ-E水平、毒性评分和癫痫控制之间存在弱相关性，但同时服用其他药物时则不存在。CBZ、CBZ-E或它们的总和与毒性评分或癫痫发作频率之间的相关性无显著差异。测量CBZ-E水平并未提供有助于监测对CBZ治疗临床反应的额外有用信息。
