Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.
Animal Health Diagnostic Center, Cornell University, Ithaca, NY, 14852, USA.
Arch Virol. 2019 Nov;164(11):2843-2848. doi: 10.1007/s00705-019-04398-4. Epub 2019 Sep 7.
The Cooper and Los Angeles (LA) strains were the two original respiratory strains of bovine herpesvirus type 1.1 (BoHV-1.1) isolated in the 1950s from cattle with infectious bovine rhinotracheitis. We report the complete genome sequence for the BoHV-1.1 LA strain and compare it to the prototype Cooper strain and six wild-type BoHV-1.1 isolates. A nucleotide sequence divergence of 0.74% was noted across the two complete genomes, caused by 19 single-nucleotide polymorphisms (SNPs) involving 12 genes and insertions/deletions that primarily affected the number of repeats within reiterated repeat regions of the genome. Phylogenetic analysis revealed that Cooper and LA strains are genetically the most ancient strains from which all of the more-recently isolated field strains of BoHV-1.1 evolved.
库珀株和洛杉矶株是两种最初从患有传染性牛鼻气管炎的牛中分离出来的牛疱疹病毒 1 型 1.1 株（BoHV-1.1）。我们报告了 BoHV-1.1 洛杉矶株的完整基因组序列，并将其与原型库珀株和六个野生型 BoHV-1.1 分离株进行了比较。在两个完整基因组之间发现了 0.74%的核苷酸序列差异，这是由 19 个单核苷酸多态性（SNP）引起的，涉及 12 个基因和插入/缺失，这些变化主要影响基因组中重复重复区域内的重复次数。系统发育分析表明，库珀株和洛杉矶株是所有最近分离的 BoHV-1.1 野毒株中最古老的毒株。
