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在意大利中部一次疫情中分离出的野生型（BoAHV-1）毒株的基因组特征分析

Genomic Characterization of a Wild-Type (BoAHV-1) Strain Isolated in an Outbreak in Central Italy.

作者信息

Petrini Stefano, Curini Valentina, Righi Cecilia, Cammà Cesare, Di Lollo Valeria, Tinelli Elena, Mincarelli Luana Fiorella, Rossi Elisabetta, Costantino Giulia, Secondini Barbara, Pirani Silvia, Giammarioli Monica, Feliziani Francesco

机构信息

National Reference Centre for Infectious Bovine Rhinotracheitis (IBR), Istituto Zooprofilattico Sperimentale Umbria-Marche "Togo Rosati", 06126 Perugia, Italy.

National Reference Center for Whole Genome Sequencing of Microbial Pathogens, Istituto Zooprofilattico Sperimentale Abruzzo-Molise "G. Caporale", 64100 Teramo, Italy.

出版信息

Viruses. 2024 Jan 19;16(1):150. doi: 10.3390/v16010150.

DOI:10.3390/v16010150
PMID:38275960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10818397/
Abstract

(BoAHV-1) infection is common in cattle worldwide. However, information on the spread of BoAHV-1-circulating strains in Italy remains limited. In this study, we investigated an outbreak characterized by severe respiratory symptoms in a cattle herd ( = 30) located in Central Italy. BoAHV-1 was isolated from three cattle in a cell culture, which confirmed viral infection. Next, we characterized one (16453/07 TN) of the three isolates of BoAHV-1 using whole-genome sequencing. BLASTn and phylogenetic analysis revealed a nucleotide identity >99% with all BoAHV-1 strains belonging to subtype 1.1, highlighting the genetic stability of the virus. This study reports the first full genomic characterization of a BoAHV-1 isolate in Italy, enriching our understanding of the genetic characteristics of the circulating BoAHV-1 strain in Italy.

摘要

牛α疱疹病毒1型（BoAHV - 1）感染在全球范围内的牛群中很常见。然而，关于BoAHV - 1流行毒株在意大利传播的信息仍然有限。在本研究中，我们调查了意大利中部一个牛群（n = 30）中以严重呼吸道症状为特征的一次疫情。在细胞培养中从三头牛分离出BoAHV - 1，这证实了病毒感染。接下来，我们使用全基因组测序对BoAHV - 1的三个分离株之一（16453/07 TN）进行了特征分析。BLASTn和系统发育分析显示，与所有属于1.1亚型的BoAHV - 1毒株的核苷酸同一性>99%，突出了该病毒的遗传稳定性。本研究报告了意大利BoAHV - 1分离株的首次全基因组特征分析，丰富了我们对意大利流行的BoAHV - 1毒株遗传特征的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fce/10818397/63110d0f4160/viruses-16-00150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fce/10818397/63110d0f4160/viruses-16-00150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fce/10818397/63110d0f4160/viruses-16-00150-g001.jpg

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The Cell-Mediated Immune Response against (BoHV-1) Infection and Vaccination.针对（牛疱疹病毒1型，BoHV - 1）感染和疫苗接种的细胞介导免疫反应。
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