Liu Y F, Jia C, Zhang M, Chen G S, Zhang N, Fu L B, Wang L, He L J
Department of Pathology, Beijing Children's Hospital, Beijing 100045, China; Department of Pathology, Xi'an Children's Hospital, Xi'an 710043, China.
Department of Pathology, Beijing Children's Hospital, Beijing 100045, China.
Zhonghua Bing Li Xue Za Zhi. 2019 Sep 8;48(9):705-709. doi: 10.3760/cma.j.issn.0529-5807.2019.09.008.
To investigate histopathological characteristics, and differential diagnoses of childhood synovial sarcoma. HE staining, immunohistochemical staining and fusion gene detection by FISH were performed in 12 cases of synovial sarcoma in childhood at Beijing Children's Hospital from 2016 to 2018. There were 6 cases of biphasic type, 1 case of monophasic epithelial type, 3 cases of monophasic spindle cell type and 2 cases of poorly differentiated synovial sarcomas. EMA, CKpan, bcl-2, CD99, TLE1 and CD34 immunostain positivities were observed in 10/12, 9/12, 12/12, 10/12, 10/12 and 0/12 cases respectively. Unique INI1 immunohistochemical staining was observed in 9/12 cases. SS18-SSX gene fusion was detected in 8 of 11 cases by FISH. Synovial sarcoma is rare in children. Histological morphology combined with immunohistochemistry and FISH SS18-SSX fusion gene detection are important for the diagnosis and differential diagnosis of synovial sarcoma in children.
探讨儿童滑膜肉瘤的组织病理学特征及鉴别诊断。对2016年至2018年在北京儿童医院就诊的12例儿童滑膜肉瘤进行苏木精-伊红（HE）染色、免疫组织化学染色及荧光原位杂交（FISH）检测融合基因。其中双相型6例，单相上皮型1例，单相梭形细胞型3例，低分化滑膜肉瘤2例。EMA、CKpan、bcl-2、CD99、TLE1及CD34免疫染色阳性率分别为10/12、9/12、12/12、10/12、10/12及0/12。12例中有9例观察到独特的INI1免疫组织化学染色。11例中有8例通过FISH检测到SS18-SSX基因融合。儿童滑膜肉瘤罕见。组织形态学结合免疫组织化学及FISH检测SS18-SSX融合基因对儿童滑膜肉瘤的诊断及鉴别诊断具有重要意义。
